Transposable elements are discrete segments of DNA that are able to amplify by moving from one genomic location to another. They are virtually present in every living organisms and represent a significant part of the genome of higher organisms. Our lab is interested in different aspects of transposable elements using an approach combining biochemistry, next generation sequencing (RNA-Seq and ChIP-Seq), cell biology, bioinformatics and mathematical modelling.
Our current projects are:
– To determine the mechanism of mariner transposition
– To find the functions of SETMAR, a fusion between a SET domain and primate-specific domesticated transposase
– To engineer mariner transposons and their derivatives as gene vectors
Bouuaert CC, Tellier M, Chalmers R. One to rule them all: A highly conserved motif in mariner transposase controls multiple steps of transposition. Mob Genet Elements. 2014 Jan 1;4(1):e28807. Epub 2014 Apr 14.