Home

Transposable elements are discrete segments of DNA that are able to amplify by moving from one genomic location to another. They are virtually present in every living organisms and represent a significant part of the genome of higher organisms.  Our lab is interested in different aspects of transposable elements using an approach combining biochemistry, next generation sequencing (RNA-Seq and ChIP-Seq), cell biology, bioinformatics and mathematical modelling.

Our current projects are:
– To determine the mechanism of mariner transposition
– To find the functions of SETMAR, a fusion between a SET domain and primate-specific domesticated transposase
– To engineer mariner transposons and their derivatives as gene vectors

 

Last publication

Bouuaert CC, Tellier M, Chalmers R. One to rule them all: A highly conserved motif in mariner transposase controls multiple steps of transposition. Mob Genet Elements. 2014 Jan 1;4(1):e28807. Epub 2014 Apr 14.

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out / Change )

Twitter picture

You are commenting using your Twitter account. Log Out / Change )

Facebook photo

You are commenting using your Facebook account. Log Out / Change )

Google+ photo

You are commenting using your Google+ account. Log Out / Change )

Connecting to %s